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Getting an IgG4-RD diagnosis can be a long and complicated journey, but it’s an important first step toward managing your health.
Diagnosing IgG4-RD Is a Team Effort
Diagnosing IgG4-RD often involves a team of specialists who work together to address the many ways the condition can affect the body. Each expert contributes a unique perspective to understanding the symptoms, identifying the organs involved, and ensuring no detail is missed.
Your IgG4-RD Care Team
Depending on your symptoms, your care team may include:
How Is IgG4-RD Diagnosed?

Clinical History & Physical Examination
Your healthcare provider will review your symptoms, medical history, and perform a physical exam to look for signs of IgG4-RD.

Serum IgG4 Testing
A blood test can measure IgG4 levels, but not all patients with IgG4-RD have high levels.

Other Blood Tests
Additional tests may be ordered to measure inflammation, immune system activity, or other levels.

Imaging Tests (CT/MRI)
CT or MRI scans can help identify affected organs by detecting inflammation or scarring.

Biopsy (Histopathology)
A biopsy is a simple procedure where a small tissue sample is taken to check for disease. For IgG4-RD, it’s the best way to confirm the diagnosis by looking for signs like inflammation, scarring, and cells linked to the condition.
The Challenges of Diagnosis
Diagnosing IgG4-RD can take time, as its symptoms often resemble other conditions like cancer or autoimmune diseases. While the process may feel challenging, each step helps bring you closer to answers and the care you need.
IgG4-RD flares can happen over time, so regular checkups and monitoring are important. Staying in touch with your healthcare team can help catch changes early and manage symptoms. If you notice any new symptoms, contact your doctor right away—early detection and proper management can make a big difference!
CT, computed tomography; IgG4, immunoglobulin G4; IgG4-RD, immunoglobulin G4-related disease; MRI, magnetic resonance imaging.